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| Du,C.W.; Wen,B.G.; Li,D.R.; Peng,X.; Hong,C.Q.; Chen,J.Y.; Lin,Z.Z.; Hong,X.; Lin,Y.C.; Xie,L.X.; Wu,M.Y.; Zhang,H.. |
| Nasopharyngeal carcinoma (NPC) is notorious for the metastases, which are in close association with Epstein-Barr virus-encoded latent membrane protein 1 (LMP1). Arsenic trioxide (As2O3) has been shown to induce apoptosis and differentiation in NPC xenografts. Then, can it repress the cancer cells' metastasis potential? To elucidate this issue, the present study was performed. LMP1-negative cell line HNE1 and LMP1-positive cell line HNE1-LMP1 were used as in vitro model. Cells (1 x 10(5)/mL) were cultured with or without 3 µM As2O3 for 48 h. Then the survival cells were collected to investigate their potential of colony formation, attachment, invasion, and migration. Both confocal immunofluorescence staining and Western blot were used to detect the changes... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Arsenic trioxide (As2O3); Nasopharyngeal carcinoma; Metastases; Latent membrane protein 1; Metalloproteinase 9. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000500015 |
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| Jiang,T.; Jiang,C.-Y.; Shu,J.-H.; Xu,Y.-J.. |
| The molecular mechanism of nasopharyngeal carcinoma (NPC) is poorly understood and effective therapeutic approaches are needed. This research aimed to excavate the attractor modules involved in the progression of NPC and provide further understanding of the underlying mechanism of NPC. Based on the gene expression data of NPC, two specific protein-protein interaction networks for NPC and control conditions were re-weighted using Pearson correlation coefficient. Then, a systematic tracking of candidate modules was conducted on the re-weighted networks via cliques algorithm, and a total of 19 and 38 modules were separately identified from NPC and control networks, respectively. Among them, 8 pairs of modules with similar gene composition were selected, and 2... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Nasopharyngeal carcinoma; Protein-protein interaction; Attract; Module; Cell division. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000800602 |
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| Xing,Haijie; Chen,Xiangdong; Han,Yaofeng. |
| Abstract Background Regenerating gene IA (REGIA) plays an important role in tissue regeneration and tumors prognosis of epithelium origin. However, the role of REGIA in nasopharyngeal carcinoma (NPC) is unclear. This study aims to investigate the expression and function of REG1A in NPC. Results We have found that there was 63 patients with REGIA positive expression of 155 patients in this study (40.65%). The positive expression rate of REGIA was 30.50, 44.44 and 47.83% in stage T2, T3 and T4 patients, respectively. The REGIA expression was significantly difference in T2 and T4 stage tumors or T2 and T3–T4 stage. The positive expression rate of REGIA was found to be higher in patients with cervical lymph node persistence than those with cervical... |
| Tipo: Journal article |
Palavras-chave: Nasopharyngeal carcinoma; Regenerating gene IA; Invasion; Survival. |
| Ano: 2017 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602017000100227 |
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| Qiu,Qing-chao; Hu,Bo; He,Xiu-pei; Luo,Qiao; Tang,Guo-hua; Long,Zhi-feng; Chen,Zhu-chu; He,Xiu-sheng. |
| STGC3 is a potential tumor suppressor that inhibits the growth of the nasopharyngeal carcinoma cell line CNE2; the expression of this protein is reduced in nasopharyngeal carcinoma compared with normal nasopharyngeal tissue. In this study, we investigated the tumor-suppressing activity of STGC3 in nude mice injected subcutaneously with Tet/pTRE-STGC3/CNE2 cells. STGC3 expression was induced by the intraperitoneal injection of doxycycline (Dox). The volume mean of Tet/pTRE-STGC3/CNE2+Dox xenografts was smaller than that of Tet/pTRE/CNE2+Dox xenografts. In addition, Tet/pTRE-STGC3/CNE2+Dox xenografts showed an increase in the percentage of apoptotic cells, a decrease in Bcl-2 protein expression and an increase in Bax protein expression. A proteomic approach... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: CNE2 cell line; Nasopharyngeal carcinoma; Nude mouse; STGC3; Tet-on; Two-dimensional electrophoresis. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000100002 |
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